We recommend linear settings for most live mixing situations.6-point hermite is the fastest interpolation method and so is suitable for 'real-time' playback, providing superior quality to 'linear' interpolation. The options are the same for both locations, they are:Linear interpolation provides the lowest CPU hit with basic linear averaging between samples, however this may result in aliasing (high frequency noises) when samples are transposed far from their original pitch. The other interpolation setting is found on the export dialog and affects audio file quality (and render time). Here in the Audio Settingsthe interpolation method affects the 'live' audio quality (and CPU load if your project contains transposed Sampler and Audio Clip Channels). This video covers the concepts of aliasing and Interpolation in more detail.There are two independent locations where interpolation method can be set. The benefits of higher quality interpolation will only apply to transposed sounds.

This is necessary when samples are transposed from their original pitch to avoid 'quantizing' and/or 'aliasing' noise. Resampling - is the process of smoothly creating changes in sample data when the system is called to 'invent' intermediate volume levels between any two known sample points.

Fl studio resampling quality